1P-LSD

1P-LSD

1P-LSD, or 1-Propionyl-d-lysergic acid diethylamide, is a fascinating psychedelic from the lysergamide family. Many people often compare it to its more famous cousin, but it’s generally seen as a milder option. This is largely because it binds to brain receptors less intensely than LSD does.

To break it down a bit: 1P-LSD has a 67-fold lower binding capacity for the 5-HT1A receptors and is 13 times less active at the 5-HT2A receptors . Interestingly, it does show a 3.5-fold increase in activity at the h5-HT2C receptors.

But here’s where it gets interesting—1P-LSD acts as a prodrug. This means that when you take it, your liver transforms it into LSD, which is what gives you those psychoactive effects. The bioavailability  is nearly 100%, making it quite effective.

While 1P-LSD is closely related to LSD and shares similar effects, it’s still a distinct compound. It’s also related to ALD-52, another psychedelic. Since 2015, it has been available online, and its popularity has been on the rise among those curious about psychedelics.

What About 1P1P-LSD?

You might also hear about 1P1P-LSD, another variant in the same family. This psychedelic shares some similarities with both 1P-LSD and ALD-52, but it comes with its own unique characteristics. The key difference lies in the addition of a propionyl group to the indole nitrogen, which alters how it interacts with our brains.

The Science Behind Lysergamides

When we talk about lysergamides, we’re diving into a class of molecules that includes 1P-LSD. While we don’t have extensive documentation of the side effects , many people believe they’re similar to those of LSD, which has been studied much more thoroughly.

One important thing to keep in mind is that 1P-LSD doesn’t linger for too long. Its effects typically last around four hours before it’s metabolized into LSD.

In summary, while they share some similarities, they’re not the same.

offers a unique experience, especially for those wanting to explore the world of psychedelics. Whether you’re just curious about how it feels or are considering trying it, it’s always wise to approach with caution and an open mind.